Catalog No. :	HL1019
Product Name :	Triptolide
CAS No. :	38748-32-2
Synonyms :	PG 490; NSC163062;
Chemical Name :	(6aS,7aS,8R,8aR,9aS,9bS,10aS,10bS)-8-hydroxy-8a-isopropyl-10b-methyl-1,5,5b,6,6a,8,8a,9a,9b,10b-decahydrotris(oxireno)[2',3':4b,5;2'',3'':6,7;2''',3''':8a,9]phenanthro[1,2-c]furan-3(2H)-one.
Molecular Formula :	C20H24O6
Molecular Weight :	360.40
Molecular Structure :
Appearance :	white solid powder
Specification :	98+%
Application :	NF-κB activation inhibitor
Registration :
Storage Condition :	4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Triptolide is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii. It functions as a NF-κB inhibitor with dual actions by disruption of p65/CBP interaction and by reduction of p65 protein. Triptolide (PG490) abrogates the transactivation function of heat shock transcription factor 1 (HSF1). Triptolide inhibits MDM2 and induces apoptosis through a p53-independent pathway.

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