中文版
Bioactive Small Molecules
(S,S)-ICG 001
Catalog No. :
C13753
Product Name :
(S,S)-ICG 001
CAS No. :
847591-62-2
Synonyms :
ICG 001; ICG001;ICG-001
Chemical Name :
(6S,9aS)-Hexahydro-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
Molecular Formula :
C33H32N4O4
Molecular Weight :
548.63
Molecular Structure :
Appearance :
Specification :
98%Min.HPLC
Application :
Registration :
Storage Condition :

Biological ActivitySpecific inhibitor of Wnt/β-catenin signaling pathway; inhibiting β-catenin/cyclic AMP response element-binding (CREB) protein transcription. ICG-001 selectively induces apoptosis in transformed cells but not in normal colon cells, reduces in vitro growth of colon carcinoma cells, and is efficacious in the Min mouse and nude mouse xenograft models of colon cancer.

Statement:
->>Products covered by valid patents are not offered or supplied for commercial use.
->>Products currently covered by valid US Patents are offered for laboratory R&D use in accordance with 35 USC 271(e)+A13(1).
->>Any patent infringement and resulting liability is solely at buyer's risk.
->>Our products are only raw materials for drugs or industry, can't be used for human or animals directly.

  • Biological ActivitySpecific inhibitor of Wnt/β-catenin signaling pathway; inhibiting β-catenin/cyclic AMP response element-binding (CREB) protein transcription. ICG-001 selectively induces apoptosis in transformed cells but not in normal colon cells, reduces in vitro growth of colon carcinoma cells, and is efficacious in the Min mouse and nude mouse xenograft models of colon cancer.
  • Necrosulfonamide

    Lurbinectedin (PM01183)

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